Song, Hong published the artcileSynthesis and herbicidal activity of novel 4-acyl-2,5-disubstituted-3-hydroxypyrazoles and 4-arylcarbonyl-3-substituted-isoxazol-5-ones, Computed Properties of 1076-59-1, the publication is Journal of Heterocyclic Chemistry (2013), 50(6), 1381-1385, database is CAplus.
Novel 2,5-disubstituted 4-acyl-3-hydroxypyrazoles I and II (R = Me, R1 = Ph; R = Me, R1 = 4-ClC6H4; R = Me, R1 = 4-FC6H4; R = R1 = Ph) and 4-aroylisoxazol-5-ones III (R = Me, R1 = Ph, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 2-FC6H4, 4-FC6H4, 4-MeC6H4; R = Ph, R1 = 2-ClC6H4, 4FC6H4) were synthesized by Schotten-Baumann reaction of acyl chlorides with appropriate 2,4-dihydropyrazol-3-ones and 4H-isoxazol-5-ones, resp., followed by Fries rearrangement in the presence of Ca(OH)2 and CaO as the catalyst. 1H NMR indicated that I and II existed in enol forms and III in keto configurations. Preliminary bioassays showed that some of the title compounds I–III exhibited moderate to good herbicidal activities against Brassica campestris at 100 mg/L. Isoxazoles III showed better herbicidal activity against B. campestris than pyrazoles I and II at 100 mg/L. Moreover, most of the isoxazoles displayed higher herbicidal activity against B. campestris than Echinochloa crus-galli. However, these compounds showed weak herbicidal activities at 10 mg/L.
Journal of Heterocyclic Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C8H7NaO4S, Computed Properties of 1076-59-1.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem