With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.925006-96-8,Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: The ethyl ester intermediate 15 (2mmol) was dissolved in 98 ethanol/120 water (3:1, 10mL), and 19 NaBH4 (0.38g, 10mmol) was added. The reaction mixture was sealed with a balloon and stirred overnight at room temperature. Upon the completion of reduction, the solution was partitioned between EtOAc (40mL) and 1N HCl (25mL). The organic layer was washed with saturated NaHCO3 and brine, dried over Na2SO4, concentrated in a rotovapor. The alcohol was used directly for next step without purification., 925006-96-8
The synthetic route of 925006-96-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Bi, Fangchao; Song, Di; Zhang, Nan; Liu, Zhiyang; Gu, Xinjie; Hu, Chaoyu; Cai, Xiaokang; Venter, Henrietta; Ma, Shutao; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 90 – 103;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem