With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78967-07-4,Mofezolac,as a common compound, the synthetic route is as follows.,78967-07-4
To a stirred solution of mofezolac (500 mg, 1.47 mmol) in dry CH2Cl2 (25 mL) , kept at 0C by an ice-bath, HOBt monohydrate (253 mg, 1.48 mmol) and EDC hydrochloride (303 mg, 1.58 mmol) were added. Separately a stirred solution of methyl 11-aminoundecanoate hydrochloride (370 mg, 1.38 mmol) in dry CH2Cl2 (13 mL) was mixed with DIEA (0.45 mL, 2.6 mmol) at room temperature. After 2h, this solution was dropwise added to the reaction mixture and stirred overnight at room temperature. Then, sat. aq. NaHCO3 was added and the aqueous solution extracted three times with EtOAc. The combined organic layers were dried over anhydrous Na2SO4, and the solvent distilled under reduced pressure. Column chromatography (silica gel; CHCls/MeOH = 5:5) of the crude residue afforded the product as a white solid (573 mg, 72% yield). NMR (300 MHz, CDCl3, delta) : 7.41- 7.26 (m, 2H aromatic protons) ; 7.25-7.13 (m, 2H aromatic protons) ; 6.93-6.71 (m, 4H aromatic protons), 5.80 (bs, 1H, exchanges with D20) , 3.82 (s, 3H, OC) , 3.80 ( s, 3H, OCH3) , 3.67 (s, 2H, CH2) , 3.65 (s, 3H, COOC) , 3.23- 3.21 (m, 2H, NHC), 2.31-2.26 (t, 2H, CCO) , 1.62-1.57 (m, 2H, CCH2CO) , 1.49-1.45 (m, 2H, CCH2NH) ; 1.25-1.10 (m, 12H, CH2) . ESI/MS m/z: C3iH4oN206 (M + Na)+: 559.
78967-07-4 Mofezolac 4237, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI BARI “ALDO MORO”; SCILIMATI, Antonio; PERRONE, Maria Grazia; VITALE, Paola; (114 pag.)WO2017/187352; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem