With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.
General procedure: (0.184 g,1 mmol) was added into a 25 mL one-necked round-bottom flask with 5mL of dry iso-PrOH, and the mixture was stirred in a cold bath. Then a solution of Et3N (0.101 g, 1 mmol) and (3-phenyl-isoxazole-5-yl)-methanol (0.175 g, 1 mmol) in 10mL dry iso-PrOH was slowly added to the reaction system using a syringe. The mixture was stirred in a cold bath for an additional 30 min, and then tem-perature was allowed to reach room temperature. After reaction completion (monitored by thin layer chromatography, TLC), the reaction mixture was evaporated under reduced pressure, and the residue was purified by column chromatog-raphy on silica gel using petroleum ether and ethyl acetate (V/V, 5:1?2:1) as eluant. Fractions with similar Rf values were combined to obtain the target compound 3a., 206055-91-6
206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Yong, Jianping; Lu, Canzhong; Wu, Xiaoyuan; Letters in drug design and discovery; vol. 15; 5; (2018); p. 463 – 474;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem