With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.
5-ethyl-6-methyl-4-phenylthieno[2,3-d] pyrimidin-2(1H)-one (2a,2 g, 7.4 mmol) and 4-(chloromethyl)-3,5-dimethylisoxazole (0.94 mL,8.9 mmol) were put into 100 mL round bottom flask, then 50 mL dimethylsulfoxide as solvent and 0.1 g potassium carbonate used ascatalyst for the reaction were added. The reaction mixture was heatedat 110 C for 1.5 h. The reaction mixture was then diluted with 100 mLdichloromethane and washed with brine (50 mL¡Á3). The organicsolvent was removed under vacuum. The residue dissolved in ethylacetate and purified with silica gel column chromatography (producteluted at 100% [v/v] ethyl acetate/petroleum ether) to afford 1-((3,5-dimethylisoxazol-4-yl)methyl)-5-ethyl-6-methyl-4-phenylthieno[2,3-d]pyrimidin-2(1H)-one (3a) as a yellow crystal.
19788-37-5, 19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Ma, Junlong; Chen, Heng; Yang, Jie; Yu, Zutao; Huang, Pan; Yang, Haofeng; Zheng, Bifeng; Liu, Rangru; Li, Qianbin; Hu, Gaoyun; Chen, Zhuo; Bioorganic and Medicinal Chemistry; vol. 27; 9; (2019); p. 1871 – 1881;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem