With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
Reference Production Example 87 (0729) 60% Sodium hydride (1.40 g, 35.08 mmol) was added to dehydrated N,N-dimethylformamide (20 ml) cooled to 0C, under a nitrogen atmosphere, and a dehydrated N,N-dimethylformamide (10 ml) solution of ethyl 5-hydroxymethylisoxazole-3-carboxylate (4.0 g, 23.39 mmol) was added dropwise thereto over 10 minutes, and then the mixture was further stirred for 30 minutes. A dehydrated N,N-dimethylformamide (10 m) solution of 2-bromomethyl-5-chlorothiophene (3.9 g, 23.39 mmol) was added thereto, and the mixture was heated to room temperature and stirred for 16 hours. The reaction mixture was added to a saturated aqueous ammonium chloride solution, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with water and saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 2.6 g of ethyl 5-(5-chlorothiophen-2-ylmethyl)oxymethylisoxazole-3-carboxy late represented by the following formula. 1H-NMR (CDCl3, TMS, delta (ppm)) : 6.80 (m, 2H), 6.68(s, 1H), 4.65 (s, 4H), 4.43 (q, 2H), 1.42 (t, 3H), 123770-62-7
123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem