With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (0.270 g) was dissolved in absolute ethanol (4.5 ml). Methylamine (2M in THF, 3.16 ml) was added. The vial was sealed and stirred at 70C overnight. The reaction mixture was cooled to room temperature and the solvent was evaporated in vacuo. The crude product was purified via flash column chromatography (1-4% methanol in dichloromethane) affording the product as a white solid, 123770-62-7
123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; Dr. August Wolff GmbH & Co. KG Arzneimittel; Soeberdt, Michael; Knie, Ulrich; Abels, Christoph; EP2666766; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem