With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 7 (COMPOUND 20)3-Methylcarbamoylisoxazol-5-ylmethyl 2-[1-(6-chloroquinolin-2-yl)piperidin-4-yl]ethylcarbamate7.1. Ethyl 5-{2-[1-(6-chloroquinolin-2-yl)piperidin-4-yl-ethylcarbamoyloxymethyl}isoxazole-3-carboxylateThe process is performed according to the procedure described in Example 1 (step 1.7.). Starting with 0.5 g (1.1 mmol) of 4-nitrophenyl 2-[1-(6-chloroquinolin-2-yl)piperidin-4-yl]-ethylcarbamate, described in Example 6 (step 6.4.), 0.311 g (2.2 mmol) of N,N-diisopropylethylamine, 0.067 g (0.55 mmol) of N,N-dimethylaminopyridine and 0.188 g (1.1 mmol) of ethyl 5-hydroxymethylisoxazole-3-carboxylate, and after chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 0.4 g of pure product is obtained in the form of a white powder.m.p. ( C.): 113-115 C.1H NMR (CDCl3) delta (ppm): 7.70 (d, 1H); 7.50 (m, 1H); 7.45 (m, 1H); 7.35 (m, 1H); 6.90 (d, 1H); 6.65 (s, 1H); 5.20 (s, 2H); 4.70 (m, 2H); 4.50-4.30 (m, 5H); 3.20 (m, 2H); 2.90 (broad t, 2H); 1.80 (broad d, 2H); 1.60-1.20 (m, 6H)., 123770-62-7
123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; SANOFI-AVENTIS; US2012/15950; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem