With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.
To a solution of 3- (trifluoromethyl) isoxazol-5-amine (0.047 g, 0. 308, mmol) in DMF (6.0 ml) is added NaH 60% dispersion in mineral oil (0.012 g, 0.308 mmol). After stirring the mixture at RT for 15 min phenyl 4-ETHOXY-2- (1, 3-oxazol-2-yl) phenylcarbamate (0.1 g, 0.308 mmol) is added and the reaction mixture is heated at 50oC FOR 30 MIN. The mixture is neutralized with 0. 1M HCl, extracted with EtOAc, and the combined organic layers are dried (MGS04), filtered, and concentrated under vacuum. The residue is purified by silica gel chromatography (40% EtOAc/heptane) followed by the trituration with CH2C12/HEPTANE to afford Example 17 as a white solid 0.103 g (87%). HRMS (ESI) calcd for C16HL3N404F3+H 383.0967, found 383.0961., 108655-63-6
108655-63-6 3-(Trifluoromethyl)isoxazol-5-amine 13913996, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/85433; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem