With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.
PREPARATIVE EXAMPLE 13.23; Step A; To a stirred solution of acid (630mg) from Preparative Example 13.19, Step B in CH2CI2 (25mi) was added oxalyl chloride (235ul) followed by a catalytic amount of DMF (10ul). The mixture was stirred for 1 hr, then potassium carbonate (1.8g) was added followed by 3-amino-5-methylisoxazole (443mg). The reaction stirred overnight and was quenched with water (25ml). Layers were separated and the organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The crude product was purified by preparative plate chromatography (CH2CI2) to afford the product (580mg, 78%, MH+=317,319).
1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/66147; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem