300-87-8, Name is 3,5-Dimethylisoxazole, belongs to isoxazole compound, is a common compound. Recommanded Product: 300-87-8In an article, once mentioned the new application about 300-87-8.
6pi electrocyclization has attracted interest in organic synthesis because of its high stereospecificity and atom economy in the construction of versatile 5?7-membered cycles. However, examples of asymmetric 6pi electrocyclization are quite scarce, and have to rely on the use of chiral organocatalysts, and been limited to pentadienyl-anion- and triene-type 6pi electrocyclizations. Described herein is a zinc-catalyzed formal [4+3] annulation of isoxazoles with 3-en-1-ynol ethers via 6pi electrocyclization, leading to the site-selective synthesis of functionalized 2H-azepines and 4H-azepines in good to excellent yields with broad substrate scope. Moreover, this strategy has also been used to produce chiral 2H-azepines with high enantioselectivities (up to 97:3 e.r.). This protocol not only is the first asymmetric heptatrienyl-cation-type 6pi electrocyclization, but also is the first asymmetric reaction of isoxazoles with alkynes and the first asymmetric catalysis based on ynol ethers.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 300-87-8
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem