1008-75-9, Name is 3-Methyl-5-phenylisoxazole, belongs to isoxazole compound, is a common compound. name: 3-Methyl-5-phenylisoxazoleIn an article, once mentioned the new application about 1008-75-9.
In the presence of hexacarbonylmolybdenum, substituted isoxazoles undergo a cycloaddition reaction with dimethyl acetylenedicarboxylate across the C-4-C-5 bond to give 3,4-bis(methoxycarbonyl)pyridine derivatives.In a similar cycloadition of isoxazoles with methyl propiolate, 4-(methoxycarbonyl)pyridine derivatives were also obtained.The beta-carbon atom of methyl propiolate could intervene in the bonding with the C-5 position of the isoxazoles regioselectively.A mechanism involving a complexed 2-oxa-3-azabicyclo<3.2.0>hepta-3,6-diene derivative and the subsequent N-Oand C-1-C-5 bond cleavage leading to a complexed (beta-ketovinyl)nitrene intermediate is proposed for the formation of pyridine derivatives.In order to clarify the mechanistic aspect, the reaction of 4-phenyl-2-oxa-3-azabicyclo<3.2.0>hepta-3,6-diene and its related compounds were also studied to give pyridine derivatives.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem