288-14-2, Name is Isoxazole, belongs to Isoxazoles compound, is a common compound. Formula: C3H3NOIn an article, once mentioned the new application about 288-14-2.
3 Peptide Deformylase Inhibitors
The successful development of numerous antibiotics in the 1930s-1960s [1] created the complacent feeling in the medical and scientific communities that bacterial infections had been defeated, resulting in a decrease in academic and industrial research in the antimicrobial area. Unfortunately, bacteria adapted to their hostile new environment by developing or acquiring resistance mechanisms that eventually rendered many of these antibiotics ineffective. Currently, infectious diseases are still a leading cause of death in the world [2], while the approval of new antibacterial agents has been steadily decreasing over the last 20 years [3]. Although the development of second- and third-generation antibiotics from existing classes has improved their activity and safety, bacterial resistance to these drugs continues to increase. In order to directly address this issue, antimicrobial agents with novel mechanisms of action are needed. However, of the 11 new antibiotics approved by the Food and Drug Administration (FDA) in the last 7 years, only two act through a novel mechanism: linezolid, an oxazolidinone, and daptomycin, a cyclic lipopeptide, both of which have been approved for the treatment of Gram-positive bacterial infections only. While considerable effort is underway to develop next generation oxazolidinones covering a broader spectrum of community and hospital infections [4-6], the identification of new drugs that target previously untapped bacterial pathways will play a critical role in the development of antibiotics active against resistant pathogens. This article summarises the general characteristics of a novel antibacterial target, peptide deformylase (PDF) and reviews the design, structure-activity relationships (SAR) and properties of known PDF inhibitors, including pre-clinical and clinical data for the most advanced members of this class.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem