288-14-2, Name is Isoxazole, belongs to isoxazole compound, is a common compound. Application In Synthesis of IsoxazoleIn an article, once mentioned the new application about 288-14-2.
Despite the advances in technology and understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process owing to low rate of new therapeutic discovery. Among the numerous N-heterocyclic scaffolds, quinazoline core structural frameworks have received considerable attention because they form a privileged class of pharmacophores with diverse spectrum of therapeutic potential. Various conventional synthetic approaches methodologies for quinazoline synthesis by various synthetic chemists were explored in this review wherein their bases for structural validation were expatiated using analytical data and spectroscopic means such as FT-IR, UV-Visible, 1H- and 13C-NMR as well as mass spectra. Quinazoline derivatives are among the most useful heterocyclic compounds from both synthetic and medicinal chemistry aspects. They are considered as important precursors for the synthesis of various physiologically significant and pharmacologically utilized molecules. This present study unveils quinazoline core as a multifunctional nucleus which serves as a resourceful toolbox of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. Based on diverse bioactivities and pharmacological potentials were explored, quinozaline motifs were concluded to be arsenals of warfare against infectious diseases in therapeutics. Hence, quinazolines might pave way to new drug discovery for fighting infectious diseases and increase researchers? choice of quinazoline as excellent candidates for future drug design.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem