Gentile, Gabriella; Bernasconi, Giovanni; Pozzan, Alfonso; Merlo, Giancarlo; Marzorati, Paola; Bamborough, Paul; Bax, Benjamin; Bridges, Angela; Brough, Caroline; Carter, Paul; Cutler, Geoffrey; Neu, Margarete; Takada, Mia published the article 《Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors》. Keywords: pyridylthienopyridinone derivative preparation glycogen synthase kinase inhibitor structure activity.They researched the compound: 6-Chloropyridine-2-boronic Acid( cas:652148-90-8 ).Related Products of 652148-90-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:652148-90-8) here.
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3β inhibitors is reported. X-ray crystallog. reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.
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