54593-26-9,54593-26-9, 3,5-Dimethyl-4-isoxazolecarbaldehyde is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of previously synthesized N-{[4-methyl-2- (piperid in-i -yl)phenyl](5-methylfuran-2-yl)methyl}-2-(2-oxo- 2,3-dihydro-i H-indol-5-yl)acetamide Cpd.24 (75 mg, 0.16 mmol) and 3,5-dimethyl-i ,2-oxazole-4-carbaldehyde (25 mg, 0.20 mmol) in EtOH (2 mL) was added few drops ofcatalytic piperidine. The reaction mixture was heated at080 C overnight. The solvents were removed under reducedpressure. The crude material was purified by silica gelcolumn chromatography using CH2CI2/MeOH (95:5) aseluent to afford 2-{3-[(dimethyl-i 2-oxazol-4-yl)methylidene]-2-oxo-2,3-dihydro-i H-indol-5-yl}-N-{[4-methyl-2-(piperidin-i-yl)phenyl](5-methylfuran-2-yl)methyl}acetamide (80 mg, 86%) as yellow solid, mp:128C1H NMR (300 MHz, din ppm): 1.40-i .54 (m, 6H), 2.16 (s,3H), 2.20 (s, 3H), 2.22 (s, 3H), 2.24 (s, 3H), 2.50-2.60 (m,2H), 2.71-2.81 (m, 2H), 3.34 (s, i.5H), 3.44 (s, 0.5H), 5.77(d, 0.75H, J=3.OHz), 5.82 (d, 0.25H, J=2.9Hz), 5.90-5.95(m, 1H), 6.44 (d, 0.75H, J=8.3Hz), 6.49 (d, 0.25H, J=8.iHz),6.74 (d, 0.25H, J=7.8Hz), 6.78 (d, 0.75H, J=8.OHz), 6.85-6.93 (m, 2.75H), 7.11-7.13 (m, i.75H), 7.20 (s, 0.75H), 7.22(s, 0.25H), 7.41 (s, 0.25H), 7.51 (s, 0.25H), 8.68 (d, 0.75H,J=8.5Hz), 8.72 (d, 0.25H, J=8.OHz), 10.47 (s, 0.25H), 10.57(s, 0.75H); m/z: 565 [M+H]+ (calc. mass: 564).
54593-26-9 3,5-Dimethyl-4-isoxazolecarbaldehyde 289576, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; (284 pag.)WO2018/138362; (2018); A1;,
Isoxazole – Wikipedia
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