So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tian, Wan-Fa; Hu, Chun-Hong; He, Ke-Han; He, Xiao-Ya; Li, Yang researched the compound: 1-Piperidineacetic Acid( cas:3235-67-4 ).Application of 3235-67-4.They published the article 《Visible-Light Photoredox-Catalyzed Decarboxylative Alkylation of Heteroarenes Using Carboxylic Acids with Hydrogen Release》 about this compound( cas:3235-67-4 ) in Organic Letters. Keywords: visible light photoredox catalyzed decarboxylative alkylation; heteroarene alkylation carboxylic acid hydrogen carbon dioxide release. We’ll tell you more about this compound (cas:3235-67-4).
Herein, we have developed visible-light photoredox-catalyzed decarboxylating carboxylic acids for alkylation of heteroarenes under mild conditions. The transformation occurred smoothly without the requirement of stoichiometric oxidants in the presence of 0.3 equiv of base, which benefited from the release of hydrogen (H2) and carbon dioxide (CO2). Various substrates and functional groups were tolerated. Primary mechanistic studies suggest that an oxidative quenching pathway and a reductive quenching pathway are both possible in the catalytic cycle.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem