2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3,5-Dimethyl-isoxazole-4-carboxylic acid (CAS 2510-36-3, 42.3 mg, 0.30 mmol), followed by HATU (91.5 mg, 0.24 mmcl) were added to a mixture of 2-amino-1-(4-chlorophenyl)-3- methylbutan-1-one hydrochloride (Example 20a, 49.0 mg, 0.20 mmol) and DIPEA (64.0 mg,0.30 mmol) in DCM (2 mL). The resulting mixture was stirred at 30C for 16 h and evaporatedto dryness. The residue was then purified by preparative HPLC to give amide N-(1-(4- chlorophenyl)-3-methyl-1-oxobuta n-2-yl)-3,5-dimethyl-isoxazole-4-ca rboxa mide (26.3 mg, 39%).1H NMR (500 MHz, CDCI3) 5 ppm 0.81 (d, 3 H) 1.11 (d, 3 H) 2.26 (td, 1 H) 2.53 (s, 3 H) 2.68 (s,3 H) 5.72 (dd, 1 H) 6.56 (d, 1 H) 7.45 – 7.57 (m, 2 H) 7.90 – 8.02 (m, 2 H).MS (ESI) m/z 335.1 [M+H]
2510-36-3, 2510-36-3 3,5-Dimethylisoxasole-4-carboxylic acid 75636, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; ACTURUM LIFE SCIENCE AB; LINDE, Christian Erik; PAULSEN, Kim; SOHN, Daniel; SVENSSON, Mats A; VALLIN, Karl S A; WEIGELT, Dirk; MINIDIS, Alexander; WO2014/184235; (2014); A1;,
Isoxazole – Wikipedia
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