2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3,5-dimethylisoxazole-4-carboxylic acid (1000 mg, 7.09 mmol) was heated to 80 C in SOCl2 (5.17 ml, 70.8 mmol) for 30 min. The remaining solvent was evaporated and the crude material dissolved in DCM (15 ml). After cooling to 0 C Nu,Omicron-dimethylhydroxlamine hydrochloride ( 1036.8 mg, 10.6 mmol) was added and, dropwise, pyridine (0.86 ml, 10.6 mmol) and the mixture was stirred over night at rt. 1M HC1 and DCM were added and the phases were separated. After flash chromatographic separation N-methoxy-N,3,5-trimethylisoxazole-4-carboxamide (1300 mg, 7.06 mmol) was obtained.
2510-36-3, 2510-36-3 3,5-Dimethylisoxasole-4-carboxylic acid 75636, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; KARO BIO AB; WENNERSTAL, Mattias; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; HAGBERG, Lars; WO2011/42477; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem