144537-05-3, N-Methyl-5-phenylisoxazole-3-carboxamide is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of amide 3 (101 mg, 0.5 mmol) in THF (1 mL), asuspension of 60 wt % sodium hydride (100 mg, 2.5 mmol) inTHF (3 mL) was added under argon. After the mixture wasstirred vigorously for 10 min, the mixture was cooled to 0 Cand then a solution of tosyl chloride (191 mg, 1 mmol) in THF(1 mL) was slowly added. After the mixture was stirred for 3 hat 0 C, propylamine (164 muL, 2 mmol) was added, and then themixture was stirred at room temperature for 12 h. After evaporation of the solvent, the residue was dissolved into diethyl ether(5 mL), washed with water (5 mL), and the aqueous layer wasextracted with diethyl ether (2 ¡Á 5 mL). The combined organiclayer was dried over magnesium sulfate, and concentrated, andthe residue was subjected to column chromatography on silicagel to afford N-propylcarboxamide 5c (85 mg, 0.37 mol, 74%yield),
144537-05-3, 144537-05-3 N-Methyl-5-phenylisoxazole-3-carboxamide 10888957, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Asahara, Haruyasu; Arikiyo, Keita; Nishiwaki, Nagatoshi; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 1241 – 1245;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem