Product Details of 14248-66-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about Synthesis of 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles as antiulcer agents. Author is Kubo, Keiji; Oda, Katsuaki; Kaneko, Tatsuhiko; Satoh, Hiroshi; Nohara, Akira.
Many title compounds (I, R1 = H, F, alkoxy, CF3 or MeSO2, R2 and R4 = H or Me, R3 = CF3, C2F5, HCF2CF2 or CCl3) were synthesized and tested for antisecretory, antiulcer, and cytoprotective activities. Most of these compounds were superior to omeprazole in antisecretory and antiulcer potencies, and especially in protecting the gastric mucosa from ethanol-induced damage. AG-1749 (Iansoprazole) (I, R1 = R4 = H, R2 = Me, R3 = CF3), was selected for further development and clin. evaluation.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem