Simple exploration of 100499-66-9

100499-66-9, 5-Methylisoxazol-4-amine hydrochloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method 73; N-(5-Methyl- 1 ,2-oxazol-4-yl)cyclobutanecarboxamide; Cyclobutyl carbonyl chloride (26.7 ml) was added dropwise to a stirred solution of 5- methyl-l,2-oxazol-4-amine hydrochloride (30g) and TEA (80 ml) in DCM (450 ml) at EPO ambient temperature. The reaction mixture was stirred for 30 min then washed with water (150 ml), 10% aq. citric acid (2 x 100 ml), sat. aq. NaHCO3 (2 x 100 ml). The aqueous layers were re-extracted with DCM (2 x 100 ml), the combined organic extracts dried (Na2SO4), filtered and concentrated in vacuo. The residue was triturated with ether (250 ml), filtered and dried to give the title compound as a beige solid (35.3 g). NMR (300.072 MHz, CDCl3) 8.52 (s, IH), 6.60 (br.s, IH), 3.14 (quintet, IH), 2.45-2.16 (m, 5H), 2.11-1.84 (m, 2H); m/z 181.

100499-66-9 5-Methylisoxazol-4-amine hydrochloride 13033203, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/15064; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem