Related Products of 288-14-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 288-14-2, Isoxazole, introducing its new discovery.
Tetrahydroquinolines and isoxazoles are heterocyclic compounds extracted from natural sources that have shown a wide range of pharmacological properties, including cytotoxic and antitumor properties. Based on the above, it is expected that hybrids of these two molecules potentiate their action and have greater anticancer effects.Cytotoxic activity of tetrahydroquinoline and isoxazole hybrid compounds on cervical cancer cells (HeLa) was evaluated. Cytotoxic effect of eight hybrid compounds was carried out by the MTT method. For the compound with the highest cytotoxic activity, morphological analysis was performed and cytochrome crelease, effect on mitochondrial permeability transition pore (mPTP) and DNA fragmentation were determined.Fourcompounds showed cytotoxic concentrations (CC50) less than 100 muM after 48 hours of treatment.Hybrid compound 4bshowed thehighestcytotoxic effect with a CC50of 19.7 – 2.7 muM at 72h. In addition, the effect of this hybrid compound increased three times the of cytochrome c releasewith respect to control, inhibited the mPTP and induced DNA fragmentation. Tetrahydroquinoline and isoxazolehybrid compounds showed a cytotoxic effect on HeLa cervical cancer cells and the hybrid compound 4b inducedcharacteristic alterations of mitochondrial apoptosis in these tumor cells.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 288-14-2. In my other articles, you can also check out more blogs about 288-14-2
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem