Ren, Lei published the artcileEffect of celecoxib combined with parecoxib sodium for preemptive analgesia after lumbar fusion surgery, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Hebei Yixue (2017), 23(8), 1352-1356, database is CAplus.
Objective: To observe the effect of celecoxib combined with parecoxib sodium for preemptive analgesia in the treatment of early pain after lumbar fusion surgery. Methods: Between Nov. 2015 and June 2016, 105 patients who were planned to undergo posterior lumbar fusion were excluded from the history of peptic ulcer and coronary heart disease (35 cases of lumbar spinal stenosis, 50 cases of lumbar disk herniation, 20 cases of degenerative lumbar spondylolisthesis) were randomly divided into 3 groups with 35 persons in each group. Group A was given postoperative celecoxib + patient controlled analgesia (patient controlled analgesia, PCA) group, group B was postoperative parecoxib sodium + PCA pump group, and group C was celecoxib combined with parecoxib sodium + PCA pump for perioperative preemptive analgesia. There were no significant differences in disease distribution, gender, age, or weight among the three groups (P > 0.05). All patients underwent general anesthesia for tracheal intubation, posterior laminar decompression, intervertebral bone graft fusion, and pedicle screw internal fixation. The three groups of patients were given the corresponding medication regimen according to the grouping situation, and was administered with fentanyl for PCA after the operation. The observation indicators were the visual analog score, the dosage of analgesic pump drugs, and the incidence of adverse reactions such as nausea, vomiting, and constipation. Results: The postoperative analgesic effect of group C is better than that of group A and group B. The dosage of fentanyl in group C was less than that in group A and group B. The incidence of adverse reactions in group C was significantly lower than that in group A. There was no significant difference in the incidence of adverse reactions in group B and C. Conclusion: The preemptive analgesia of celecoxib combined with parecoxib sodium for early postoperative pain after lumbar posterior fusion surgery is better, and the analgesic effect is better than that of celecoxib or parecoxib sodium alone. It can reduce the amount of opioids, while reducing the incidence of adverse reactions.
Hebei Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem