Electric Literature of 17153-20-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 17153-20-7, Name is 3-Methylisoxazole-4-carboxylic acid, SMILES is CC1=NOC=C1C(=O)O, belongs to Isoxazoles compound. In a article, author is Fernandez, Jorge, introduce new discover of the category.
Isoxazole mediated synthesis of 4-(1H)pyridones: improved preparation of antimalarial candidate GSK932121
A new synthesis of the antimalarial clinical candidate GSK932121 is described. This approach has two key reactions, the selective acylation of an unprotected 3-hydroxymethyl-5-methyl isoxazole and the reductive N-O bond cleavage of the previously functionalized isoxazole derivative, to give the 4-(1H)pyridone ring present in the final structure. The complete synthesis consists of 5 steps (versus 10 steps in previously published reports) and has enabled the preparation of the material in kilogram scale to support clinical studies.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem