In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Isoxazole, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 288-14-2, name is Isoxazole. In an article，Which mentioned a new discovery about 288-14-2
Synthesis and Structure Activity Relationships of Chalcone based Benzocycloalkanone Derivatives as Adenosine A 1 and/or A 2A Receptor Antagonists
Adenosine A 1 and/or A 2A receptor antagonists hold promise for the potential treatment of neurological conditions, such as Parkinson’s disease. Herein, a total of seventeen benzocycloalkanone derivatives were synthesised and evaluated for affinity towards adenosine receptors (A 1 and A 2A AR). The obtained results allowed for the conclusion that affinity and/or selectivity of the 2-benzylidene-1-indanone and -tetralone derivatives toward A 1 and/or A 2A ARs may be modulated by the nature of the substituents (either -OH, -OCH 3 or morpholine) attached at position C4 of the 1-indanone core and C5 of the 1-tetralone core as well as the meta (C3′) and/or para (C4′) position(s) on ring B. Several compounds (2a – b, 3b – c and 4a – b) possessed affinity for the A 1 and/or A 2A AR below 10 muM. Additionally, compounds 2a, 3b and 4a were A 1 AR antagonists. These results, once again, confirmed the importance of C4 methoxy-group substitution on ring A in combination with meta (C3′) and/or para (C4′) hydroxyl-group substitution ring B of the 2-benzylidene-1-indanone scaffold leading to drug-like compounds 1h and 1j with affinity in the nanomolar-range.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem