Poomathi, Nataraj published the artcileBronsted acid catalysed eco friendly synthesis of quaternary centred C-3 functionalized oxindole derivatives, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is New Journal of Chemistry (2018), 42(18), 14817-14826, database is CAplus.
A facile atom economic and eco friendly protocol for the synthesis of biol. important quaternary centered C-3 functionalized oxindole derivatives, with a novel nucleus, in high yields was demonstrated by employing 3-hydroxy-2-oxindole, isoxazolone/pyrazolone and environmentally benevolent p-toluene sulfonic acid as a catalyst. The advantages of this protocol were wide substrate scope, practical simplicity, benign solvent and good yields. All the synthesized compounds were evaluated for their in-vitro anti-microbial activity. Several compounds exhibited good activities comparable to those of established standard drugs. Furthermore, the anti-cancer activity of compounds I [R = 5-Cl, , R1 = H, R2 = 5-Br, R = 5-Cl, , R1 = Ph, R2 = H] were preliminarly demonstrated by in-vitro evaluation against human tumor cell lines MCF-7 and Hep-2, using MTT-based assays with com. available standard drug cisplatin as a pos. control. Gratifyingly, compounds I [R = 5-Cl, , R1 = H, R2 = 5-Br, R = 5-Cl, , R1 = Ph, R2 = H] exhibited good in vitro inhibitory activities against Hep-2 and MCF-7 cell lines. These results indicate that 3-indolyl oxindole substituted isoxazole analogs may be potential lead compounds for further biol. screening.
New Journal of Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem