Development of antiinflammatory agents. I. Isoxazole derivatives was written by Park, No Sang;Kim, Hyun Sook;Min, Changhee;Choi, Joong Kwon. And the article was included in Yakhak Hoechi in 1990.Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine This article mentions the following:
3-Substituted 5-aminoisoxazole-4-carboxylates I (R = CF3, CHF2, Ph, 4-MeOC6H4, 2-, 3-, or 4-R1C6H4; R1 = F, Cl, CF3, NO2; R2 = Me) were prepared by the reaction of corresponding bromoaldoximes with cyanoacetate. I (R = CF3, R2 = Me) (II) was acylated with various aminopyridine derivatives to afford diamides. The ester group of II was hydrolyzed and decarboxylated easily to give 3-trifluoromethyl-5-aminoisoxazole. The aminoisooxazole was also converted to amides. The synthesized compounds were tested for antiinflammatory activities. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)isoxazol-5-amine (cas: 108655-63-6Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine).
3-(Trifluoromethyl)isoxazol-5-amine (cas: 108655-63-6) belongs to isoxazole derivatives. Isoxazoles present in various natural products and synthetic compounds of biological importance like antibacterial, antagonists, antiinflammatory, analgesics, and also show the applications in functional materials. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem