In an article, author is Sherin, Daisy R., once mentioned the application of 199327-61-2, Formula: C16H21N3O4, Name is 7-Methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one, molecular formula is C16H21N3O4, molecular weight is 319.3556, MDL number is MFCD12760130, category is Isoxazoles. Now introduce a scientific discovery about this category.
Mechanochemical Synthesis and Antioxidant Activity of Curcumin-Templated Azoles
A solvent-free, mechanochemical method for the synthesis of curcumin (1) derived 3,5-bis(styryl)-pyrazoles and 3,5-bis(styryl) isoxazole (2a-g) at room temperature, with very short reaction time, is reported. Such earlier structural modifications of curcumin, at its beta-diketone unit by transforming it into an isosteric pyrazole or isoxazole unit, required prolonged heating. The evaluation of the antioxidant activity of these compounds, based on DPPH, FRAP, and beta-carotene bleaching assays, showed that several of these azoles are better antioxidants than curcumin, with the isoxazole derivative 2g being overall the best. Typically, the inhibition of 2,2-diphenyl-1-picrylhydrazyl (10(-2) mmol), expressed as EC50 values, by curcumin (1), 3,5-bis(4-hydroxy-3-methoxystyryl) pyrazole (2a), and 3,5-bis(4-hydroxy-3-methoxystyryl) isoxazole (2g) are 40 +/- 0.06, 14 +/- 0.18, and 8 +/- 0.11 mu mol, respectively. Moreover, the reported method is useful in accessing 3,5-bis(4-hydroxy-3-methoxy-styryl)-1-phenylpyrazole (2b), which is important in studies related to neuroprotection and Alzheimer’s disease, and 2a and 2g, which are inhibitors of protein kinases involved in neuronal excitotoxicity.
If you are interested in 199327-61-2, you can contact me at any time and look forward to more communication. Formula: C16H21N3O4.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem