With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4
Compound 6 (11.8g, 28.06mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazole-5-carbonyl chloride (10.2g, 77.55mmol), The reaction was heated to reflux with stirring. After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.point. After the reaction solution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(2,3-dihydro-[1,4]dioxacyclohexane) Alkeno[2,3-b]pyridin-7-yl)-7-methoxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 13.8 g, yield 95.6%.
As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.
Reference£º
Patent; Zeng Qingqiang; (11 pag.)CN108570056; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem