54593-26-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54593-26-9,3,5-Dimethyl-4-isoxazolecarbaldehyde,as a common compound, the synthetic route is as follows.
[000298] 4-Piperidinone (0.92 gr, 6 mmol) was placed in a 25 ml round bottom flask and cooled to 0 C. Boron trifluoride (10 mL) was added dropwise followed by the aldehyde (1.5 gr, 12 mmol) in one portion. The reaction mixture was stirred overnight at room temperature under nitrogen atmosphere. The reaction was carefully quenched with a saturated solution of NaHCC . The solid precipitated out from the solution was filtered under reduced pressure, washed with water and EtOH to give the intermediate El-1 (Scheme 7) as a yellow solid (1.2 gr, 3.8 mmol, 63%).
As the paragraph descriping shows that 54593-26-9 is playing an increasingly important role.
Reference£º
Patent; PI THERAPEUTICS LTD.; KALID, Ori; GOTLIV, Irina; LEVY-APTER, Einat; FINKELSHTEIN BEKER, Danit; JAGTAP, Prakash; (0 pag.)WO2019/171379; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem