With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51135-73-0,Ethyl 5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.
S-MethyIisoxazole-4-carboxyiic acid:Ethyl-5-methylisoxazole-4-carboxylate 72.58 g (0.47 mol) was taken in 20% v/v aqueous sulphuric acid (193.5 ml) and refluxed for 16 hours. Toluene (73 ml) was added at 90 0C, cooled to 25 to 35 0C and stirred for 4 hours. The crystallized solid product was filtered and washed with toluene (2×36 ml) followed by water (2×72.5 ml). The product was dried under vacuum to get 27.2 g of 5-Methylisoxazole-4-carboxylic acid as an off white solid with 99.5 % HPLC purity having isomeric impurity 0.27 %
As the paragraph descriping shows that 51135-73-0 is playing an increasingly important role.
Reference£º
Patent; UNICHEM LABORATORIES LIMITED; WO2007/86076; (2007); A2;,
Isoxazole – Wikipedia
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