With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
3,5-Dimethylisoxazole-4-carboxylic acid (0.53 g), dicyclohexylcarbodiimide (1.55 g), HOBT (0.675 g) were dissolved in 30 ml of THF, and stirred for 10 minutes, then 1 g of compound 9 was added. The reaction was carried out under nitrogen for 12 hours.After the completion of the reaction, the reaction mixture was evaporated to dryness crystals crystals crystalsSpin over the column to give a white solid 0.32 g.The yield was 80%.
As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.
Reference£º
Patent; China Pharmaceutical University; Xiang Hua; Qiu Rongmao; Huang Ali; Zheng Fan; Li Haolin; Yang Qizhen; Hu Weikang; Zhang Jin; Liu Man; Chen Mingqi; Chen Deying; You Qidong; (9 pag.)CN107987116; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem