With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
To a 100 mL round-bottomed flask was added, in sequence, isoxazole-5-carboxylic acid (0.34 g, 3.0 mmol), HATU (1.4 g, 3.6 mmol), TEA (0.92 g, 9.1 mmol), DCM (40 mL), and 2-ethoxy-4-fluoroanaline (0.60 g, 3.9 mmol) at 0 C. The reaction mixture was warmed to rt and stirred for 15 h. The reaction mixture was concentrated to dryness and the residue was purified by FCC to give the title compound (0.32 g, 43% yield) as a yellow solid. MS (ESI): mass calcd. for C12H11FN2O3 250.1, m/z found 251.1 [M+H]+.
As the paragraph descriping shows that 21169-71-1 is playing an increasingly important role.
Reference£º
Patent; Janssen Pharmaceutica NV; Bacani, Genesis M.; Chai, Wenying; Edwards, James P.; Smith, Russell C.; Tichenor, Mark S.; Venable, Jennifer D.; Wei, Jianmei; (64 pag.)US2018/289706; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem