With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.
General procedure: In 100 mL three-necked flask, (3-substituted phenylisoxazol-5-yl)methanols (3a-l) (5 mmol) was poured into a stirred mixture of sodium hydride (15 mmol) and anhydrous THF (10 mL) previously cooled in glacial bath. Propargyl bromide (6 mmol, 0.47 mL) was added, and the mixture was stirred at room temperature (20-25 C) until the reaction was over by TLC monitoring. The slurry was filtrated by sabouraud funnel. Filtrate was evaporated under a vacuum to provide the crude product which was purified by column chromatography (silica gel, 200-300 mesh) using petroleum ether/ethyl acetate (phir = 4:1) to furnish the desired product 4a-l in 68-96% yield.
206055-91-6, As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.
Reference£º
Article; Zhang, Da-wei; Zhang, Yu-min; Li, Jing; Zhao, Tian-qi; Gu, Qiang; Lin, Feng; Ultrasonics Sonochemistry; vol. 36; (2017); p. 343 – 353;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem