With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.
EXAMPLE 305 Synthesis of (f?)-3-chloro-/V-(isoxazol-3-yl)-4-((1-(1-phenylethyl)piperidin-4- yl)oxy)benzenesulfonamide formate Step 1. Preparation of 3-chloro-4-fluoro-/V-(isoxazol-3-yl)benzenesulfonamide To a mixture of isoxazol-3-amine (0.500 g, 5.95 mmol), 4- dimethylaminopyridine (0.0727 g, 0.595 mmol) and pyridine (0.941 g, 1 1.9 mmol) in dichloromethane (2 mL) was added a solution of 3-chloro-4-fluoro-benzene-1-sulfonyl chloride (1.64 g, 7.14 mmol) in dichloromethane (1 mL) at 0 C. The mixture was stirred at ambient temperature for 12 h and was then diluted with water (20 mL) and extracted with dichloromethane (2 chi 30 mL). The combined organic extracts were washed with water (20 mL), dried over anhydrous sodium sulfate, and filtered. Concentration of the filtrate in vacuo and purification of the residue by preparative reverse phase HPLC, using acetonitrile in water containing 0.1 % of formic acid as eluent, afforded the title compound as a colorless solid (0.250 g, 15% yield): H NMR (400 MHz, CDCIs) 8.31 (d, J = 1.8 Hz, 1 H), 7.92-7.90 (m, 1 H), 7.76-7.74 (m, 1 H), 7.22 (t, J = 8.5 Hz, 1 H), 6.62 (s, 1 H), NH not observed; MS (ES+) m/z 276.9 (M + 1)., 1750-42-1
As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.
Reference£º
Patent; XENON PHARMACEUTICALS INC.; ANDREZ, Jean-Christophe; BURFORD, Kristen, Nicole; CHOWDHURY, Sultan; COHEN, Charles, Jay; DEHNHARDT, Christoph, Martin; DEVITA, Robert, Joseph; EMPFIELD, James, Roy; FOCKEN, Thilo; GRIMWOOD, Michael, Edward; HASAN, Syed, Abid; JOHNSON, James, Philip, Jr.; ZENOVA, Alla, Yurevna; (493 pag.)WO2017/201468; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem