With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
Reference Production Example 293 (0936) Ethyl 5-hydroxymethylisoxazole-3-carboxylate (0.86 g, 5.0 mmol) was added to dry tetrahydrofuran (25 ml), under a nitrogen atmosphere, and the mixture was cooled to 0C. 60% sodium hydride (0.40 g, 10.0 mmol) was added thereto, and the mixture was further stirred for 30 minutes. 2-Methoxybenzyl chloride (0.94 g, 6.0 mmol) was added thereto, and the reaction solution was heated to room temperature, and then the mixture was stirred for 16 hours. The reaction mixture was poured into a saturated aqueous ammonium chloride solution, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with water and saturated saline water, and then dried over sodium sulfate. The solvent was concentrated under reduced pressure, then the residue was added to ethanol (25 mL), and 2 N sodium hydroxide (15 mL) was added thereto, and then the mixture was stirred at room temperature for 16 hours. Thereafter, the resulting mixture was concentrated under reduced pressure. Dilute hydrochloric acid was added to the reaction mixture, the mixture was cooled to 0C, and the precipitated solid was filtered. The solid was dried under reduced pressure to obtain 1.15 g of 5-(2-methoxybenzyloxymethyl)isoxazole-3-carboxylic acid represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)) : 7.28-7.35(m, 2H), 6.87-6.97(m, 2H), 6.74(s, 1H), 4.71(s, 2H), 4.65(s, 2H).3.83(s, 3H), 123770-62-7
As the paragraph descriping shows that 123770-62-7 is playing an increasingly important role.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem