With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.
To a solution of 3- (trifluoromethyl) isoxazol-5-amine (0.152 g, 1.0 mmol) in THF (10 ML) is added NaH 60% dispersion in mineral oil (0.04 g, 1. 0 mmol). After stirring the mixture at RT for 15 min phenyl 4-ETHOXY-2- (2-FURYL) PHENYLCARBAMATE (0. 323 g, 1.0 mmol) is added and the reaction mixture is heated at 50oC for 1 hour. The mixture is neutralized with 0. 1M HCl, extracted with EtOAc, and the combined organic layers are dried (MGSO4), filtered, and concentrated under vacuum. The residue is triturated with CH2C12 to afford Example 15 as a yellow solid 0.188 g (50%). HRMS (ESI) calcd for C17HL4N304F3+H 382.1014, found 382. 1013., 108655-63-6
As the paragraph descriping shows that 108655-63-6 is playing an increasingly important role.
Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/85433; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem