With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.
3-amino-5-methylisooxazole (326 mg, 3.3 mmol) was dissolved in dichloromethane (6.5 mL), and ice-cooled. Thiophosgene (0.278 mL, 3.3×1.1 mmol) and sodium carbonate aqueous solution (769 mg, 3.3×2.2 mmol, 4 mL) were added, and stirred at room temperature for 2.5 hours. After the reaction, chloroform was added and washed with the saturated sodium chloride solution, dried with magnesium sulfate and the solvent was distilled off. The obtained residue was purified by Silica gel column chromatography (Biotage Isolera One, SANP 10 g, chloroform/methanol)to obtain title compound (yellow oil, 255 mg, 55.1%) ., 1072-67-9
As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.
Reference£º
Patent; CHIBA UNIVERSITY; YAKULTHONSHA COMPANY LIMITED; TAKAYAMA, HIROMITSU; YASOBU, NAOKO; KITAJIMA, MARIKO; YAEGASHI, TAKASHI; MATSUZAKI, TAKESHI; NAGAOKA, MASATO; HASHIMOTO, SHUSUKE; NISHIYAMA, HIROYUKI; SUGIMOTO, TAKUYA; ONO, MASAHIRO; (176 pag.)JP5829520; (2015); B2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem