110256-15-0, Name is 5-Cyclopropylisoxazole-3-carboxylic acid, belongs to Isoxazoles compound, is a common compound. Formula: C7H7NO3In an article, once mentioned the new application about 110256-15-0.
Synthesis and structure?activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors
Three series of pyrazolo[3,4-d]pyrimidine derivatives were synthesized and evaluated as RET kinase inhibitors. Compounds 23a and 23c were identified to show significant activity both in the biochemical and the BaF3/CCDC6-RET cell assays. Compound 23c was found to significantly inhibit RET phosphorylation and down-stream signaling in BaF3/CCDC6-RET cells, confirming its potent cellular RET-targeting profile. Different from other RET inhibitors with equal potency against KDR that associated with severe toxicity, 23c did not show significant KDR-inhibition even at the concentration of 1?muM. These results demonstrated that 23c is a potent and selective RET inhibitor.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem