One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C10H7NO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, molecular formula is C10H7NO4
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; Structure-activity relationships of neocryptolepines and 6-methyl congeners
The present report describes the synthesis and antiproliferative evaluation of certain 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines and their methylated derivatives. These 5-Me- and 6-Me-indolo[2,3-b]quinoline derivatives 10-14, 20 were prepared by amination at the C-11 position of the 11-chloro-5-methyl-5H- and 11-chloro-6-methyl-6H-indolo[2,3-b]quinolines with different substituents on the quinoline ring. The 11-aminoalkylaminomethylated 23, the homologue of 11, was prepared from the same intermediate for a further SAR study. These intermediates are accessible from 4-substituted anilines or their N-methylated analogues and methyl indole-3-carboxylate as a counterpart. The in vitro antiproliferative assay indicated that the 5-methylated derivatives 10-14 are more cytotoxic than their respective 6-methylated 6H-indolo[2,3-b]quinoline derivatives 20. Among them, N-(3-aminopropyl)-2-bromo- 5-methyl-5H-indolo[2,3-b]quinolin-11-amine 12f was the most cytotoxic with a mean IC50 value of 0.12 muM against human leukemia MV4-11 cell line, and also exhibited selective cytotoxicities against A549 (lung cancer), HCT116 (colon cancer) cell lines and normal fibroblast BALB/3T3 with IC 50 values of 0.543, 0.274 and 0.869 muM, respectively. The binding constant of products 12f and 20f to salmon fish sperm DNA were also evaluated using UV-vis absorption spectroscopy, indicating intercalation binding with a constant of 2.93 × 105 and 3.28 × 105 L mol-1, respectively.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C10H7NO4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 33282-15-4, in my other articles.
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem