Synthetic Route of 288-14-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 288-14-2, molcular formula is C3H3NO, introducing its new discovery.
Regiospecific synthesis, anti-inflammatory and anticancer evaluation of novel 3,5-disubstituted isoxazoles from the natural maslinic and oleanolic acids
Maslinic acid (1) and oleanolic acid (2) were isolated from Olea europaea L. under ultra-sonication conditions with large amounts (8.5 and 3.4 mg/g DW, respectively). Copper-catalyzed microwave-assisted 1,3-dipolar cycloaddition reactions between natural pentacyclic triterpenoid-alkyne derivatives and a series of aryl nitrile oxides, regiospecifically afforded 3,5-disubstituted isoxazoles in quantitative yields. The reaction times were shorter than those reported in the literature. Most of the compounds were evaluated for their anti-inflammatory and anti-proliferative activities. Compounds 12c, 12e, 12g, 13c and 13d found to have higher anti-inflammatory activity. The anti-proliferative evaluation towards EMT-6 and SW480 cancer cell lines indicated that most of the compounds exhibited significant anti-cancer activity. Among all triterpenic derivatives, isoxazole 12g bearing a furfuryl ring in its isoxazole moiety was found to have highest anti-inflammatory and anti-cancer activity. Therefore, this derivative can serve as a promising lead candidate for further study.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 288-14-2 is helpful to your research. Synthetic Route of 288-14-2
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem