Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C3H3NO, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 288-14-2
In this study, a new series of 4-(5-methylisoxazol-3-ylamino)thiazole derivatives incorporated with different heterocyclic moieties was synthesized and screened for their in vitro antitumor activity against human HCT-116, HePG-2 and MCF-7 cell lines. Among them, compound 3 revealed the most potent cytotoxic activity against HePG-2 cell line with IC5020.2 mug ml-1 and moderate activity with MCF-7 cell line (IC50 = 60.9 mug ml-1) in comparison with doxorubicin (IC50 = 21.6 and 26.3 mug ml-1) respectively. Furthermore, compound 5b showed the highest antitumor activity with IC50 16.2 mug ml-1. The most promising compound 3was subjected to further kinase assay study against a panel of twelve protein kinases and exhibited good EGFR inhibitory activity (95%) and moderate PI3K (p110b/p85a) and p38alphainhibitory activities (89, 85%) respectively. Molecular modeling simulation was done to explore the binding mode of the ligand 3 within active sites EGFR, PI3K (p110b/p85a) and p38alpha kinases.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem