So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kubo, Keiji; Oda, Katsuaki; Kaneko, Tatsuhiko; Satoh, Hiroshi; Nohara, Akira researched the compound: 3,5-Dimethyl-4-nitropyridine 1-oxide( cas:14248-66-9 ).Reference of 3,5-Dimethyl-4-nitropyridine 1-oxide.They published the article 《Synthesis of 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles as antiulcer agents》 about this compound( cas:14248-66-9 ) in Chemical & Pharmaceutical Bulletin. Keywords: benzimidazole fluoroalkoxypyridylmethylsulfinyl preparation antiulcer. We’ll tell you more about this compound (cas:14248-66-9).
Many title compounds (I, R1 = H, F, alkoxy, CF3 or MeSO2, R2 and R4 = H or Me, R3 = CF3, C2F5, HCF2CF2 or CCl3) were synthesized and tested for antisecretory, antiulcer, and cytoprotective activities. Most of these compounds were superior to omeprazole in antisecretory and antiulcer potencies, and especially in protecting the gastric mucosa from ethanol-induced damage. AG-1749 (Iansoprazole) (I, R1 = R4 = H, R2 = Me, R3 = CF3), was selected for further development and clin. evaluation.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem