Synthetic Route of C7H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Piperidineacetic Acid, is researched, Molecular C7H13NO2, CAS is 3235-67-4, about Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety. Author is Zakharenko, Alexandra; Khomenko, Tatyana; Zhukova, Svetlana; Koval, Olga; Zakharova, Olga; Anarbaev, Rashid; Lebedeva, Natalya; Korchagina, Dina; Komarova, Nina; Vasiliev, Vladimir; Reynisson, Johannes; Volcho, Konstantin; Salakhutdinov, Nariman; Lavrik, Olga.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy based on Top1 poison-mediated DNA damage. Several novel benzopentathiepines were synthesized and tested as inhibitors of TDP1 using a new oligonucleotide-based fluorescence assay. The benzopentathiepines have IC50 values in the range of 0.2-6.0 μM. According to the mol. modeling, the conformational flexibility of the dibutylamine group of the most effective inhibitor (3 d) allows it to occupy an advantageous position for effective binding compared to its cyclic counterparts. The study of cytotoxicity of these compounds revealed that all compounds cause an apoptotic cell death in MCF-7 and Hep G2 cells. Therefore the new class of very effective inhibitors of TDP1 was elaborated.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem