One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H5NO2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 62254-74-4, Name is 5-Methylisoxazole-3-carboxaldehyde, molecular formula is C5H5NO2
Synthesis and evaluation of the anti-proliferative and NF-kappaB activities of a library of simplified tylophorine analogs
Tylophorine and many related phenanthropiperidine alkaloids are extraordinarily potent anti-proliferative agents. Despite their impressive anti-cancer activity, clinical development of these alkaloids has been hampered by their poor solubility and neurological side effects. Although it has been suggested that developing polar phenanthropiperidines will mitigate these undesired properties, the lack of practical methods for the synthesis of such analogues has limited this effort. Here, we present a concise synthetic approach to N-substituted phenanthropiperidines, which enabled a systematic investigation of structure-activity relationships at an underexplored region of the tylophorine scaffold. This work suggests that ring E of tylophorine is essential for the anti-proliferative activity of the 6,7,10,11-tetramethoxy-1,2, 3,4-tetrahydrodibenzo[f,h]isoquinoline core scaffold.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C5H5NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 62254-74-4, in my other articles.
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem