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A series of twenty six structurally diverse alpha-aminophosphonates have been synthesized and evaluated for in vitro anti-leishmanial activity and cytotoxicity using the MTT assay. Among them, seven compounds (1-7) exhibited anti-leishmanial potency against the L. donovani promastigote with IC 50 values in the low micromolar range. The structure-activity relationships were quantitatively evaluated by a statistically reliable CoMFA model with high predictive abilities (r2pred = 0.87, r2ncv = 0.985). This journal is the Partner Organisations 2014.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem