Reference of 3084-40-0, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 3084-40-0, Name is Diethyl (hydroxymethyl)phosphonate, SMILES is OCP(OCC)(OCC)=O, belongs to Isoxazoles compound. In a article, author is Altug, Cevher, introduce new discover of the category.
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties
Two series of benzenesulfonamide containing isoxazole compounds were prepared by using conventional and microwave (MW) methods. 5-Amino-3-aryl-N-(4-sulfamoylphenyl)isoxazole-4-carboxamide derivatives were synthesized by the reaction of hydroxymoyl chlorides with 2-cyano-N-(4-sulfamoylphenyl)acetamide in the presence of triethylamine. The synthesized 5-amino isoxazoles were reacted with various benzoyl chlorides in order to obtain 5-amidoisoxazoles. The novel compounds were screened in vitro as inhibitors of four human (h) isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1): hCA I, hCA II, hCA IV and hCA VII. The derivatives of the first series were shown to possess excellent inhibitory activity against the cytosolic isoform hCA II, an antiglaucoma drug target, with Kis in the range of 0.5-49.3 nM and hCA VII, a recently validated anti-neuropathic pain target with Kis in the range of 4.3-51.9 nM. (C) 2017 Elsevier Ltd. All rights reserved.
Reference of 3084-40-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3084-40-0 is helpful to your research.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem