New method for synthesis of methyl-ketone compounds containing heterocycle was written by Luan, Anbo;Zhao, Tianyi;Huang, Qiran;Yang, Weihe. And the article was included in Guangdong Huagong in 2008.Application of 19668-85-0 This article mentions the following:
A method for the synthesis of the title compounds is reported here. Ketone compounds containing Me and heterocyclic substituents were prepared from corresponding acids by a condensation reaction with acetic anhydride. The reaction was easily carried out and the yields were 45-81%. The experiment results showed that the reaction did not proceed if the starting material did not contain an α-hydrogen. In the experiment, the researchers used many compounds, for example, 3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0Application of 19668-85-0).
3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. The weakness of this bond allows the ring opening of these heterocycles under reductive conditions. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Application of 19668-85-0
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem