Liu, Yan-jun published the artcileClinical efficacy of pretreatment with parecoxib sodium in postoperative analgesia of elderly patients with lumbar intervertebral disc protrusion, HPLC of Formula: 198470-85-8, the publication is Zhongguo Laonianxue Zazhi (2015), 35(3), 675-677, database is CAplus.
Objective: To investigate the clin. efficacy of pretreatment with parecoxib sodium in postoperative analgesia of elderly patients with lumbar intervertebral disk protrusion. Methods: 92 Cases of elderly patients with lumbar intervertebral disk protrusion were randomly divided into control group and parecoxib sodium pretreatment group (pretreatment group), 46 cases in each group. The control group was i.v. injected with 2 mL of physiol. saline before surgery, while the pretreatment group was i.v. injected with 40 mg of parecoxib sodium. Both groups were treated with analgesia pump after surgery. The visual analog scale (VAS) scores after 2, 4 and 6 h of surgery, times of patient-controlled i.v. analgesia (PCIA) after 4, 6 and 12 h of surgery, dosage of sufentanil in the analgesia pump after 24 h, and the number of patients with postoperative adverse reactions were recorded in both groups. Results: The VAS scores after 2, 4 and 6 h of surgery and times of PCIA after 4, 6 and 12 h of surgery in the pretreatment group were significantly lower than those in the control group (P < 0.05), and the dosage of sufentanil in the analgesia pump after 24 h in the pretreatment group was higher than that in the control group. The number of patients with nausea, vomiting, hypotension, fever and tachycardia in the pretreatment group was significantly lower than that in the control group (P < 0.05). Conclusion: Parecoxib sodium has effective postoperative analgesia effect on elderly patients with lumbar intervertebral disk protrusion, and can reduce the dosage of medicine in the analgesia pump and reduce adverse reactions.
Zhongguo Laonianxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem